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American Society of Microbiology ABMM Sample Questions:

1. A patient with a history of travel to an area endemic for schistosomiasis presents with hematuria. Microscopic examination of a urine sediment reveals a large oval egg with a prominent terminal spine. The MOST likely causative agent is:

A) Schistosoma haematobium
B) Schistosoma mekongi
C) Schistosoma mansoni
D) Schistosoma japonicum

2. A sputum sample from a patient with suspected pulmonary tuberculosis is submitted for AFB smear and culture. The smear is reported as positive for acid-fast bacilli (4+). Which method is considered the gold standard for confirming the identification of Mycobacterium tuberculosis complex from culture?

A) Niacin accumulation test
B) HPLC analysis of mycolic acids
C) Nucleic acid amplification test (NAAT) targeting specific MTC sequences
D) Growth rate and colony morphology on Löwenstein-Jensen media

3. A clinical microbiology laboratory encounters a Gram-negative bacillus isolated from a bloodstream infection. The isolate exhibits resistance to multiple antibiotics, including carbapenems. Further phenotypic testing reveals the production of a metallo-beta-lactamase (MBL). Which of the following antibiotic combinations might still retain activity against this isolate?

A) Aztreonam
B) Ceftazidime-avibactam
C) Piperacillin-tazobactam
D) Aztreonam-avibactam

4. A patient undergoing chemotherapy for leukemia develops a severe pneumonia. Bronchoalveolar lavage fluid is examined, revealing numerous cysts containing crescent-shaped structures upon silver staining. The patient's CD4+ T-cell count is significantly low. The MOST likely diagnosis is infection with:

A) Blastomyces dermatitidis
B) Pneumocystis jirovecii
C) Coccidioides immitis
D) Histoplasma capsulatum

5. The gut microbiome has been implicated in the pathogenesis of autoimmune diseases. Dysbiosis, a disruption in the composition and function of the gut microbiota, can lead to increased intestinal permeability and the translocation of microbial products that trigger inflammatory responses. Which of the following bacterial components is a potent activator of the innate immune system and has been linked to the development of autoimmunity?

A) Flagellin
B) Peptidoglycan
C) Lipoteichoic acid (LTA)
D) Lipopolysaccharide (LPS)

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